Supplemental Table S11 from Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype

Key Points

Cytotoxic NK cells impede response to checkpoint immunotherapy in melanoma.
Findings from CITE-seq data highlight marker genes specifically related to immune cell clusters.
The analysis involved the clustering of immune cells to identify key markers in the immune-excluded phenotype.
This study suggests a significant role of immune cells in melanoma treatment outcomes, pointing to potential therapeutic targets.

Analysis reveals that cytotoxic NK cells are linked to melanoma's immune-excluded phenotype, suggesting immune evasion challenges.

Discriminatory marker genes of clusters obtained after clustering of all immune cells from the CITE-seq mouse data (NK cells = cluster 11).

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Poźniak et al. (2025) studied this question.

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