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September 4, 2025

Supplemental Table S2 from Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype

Joanna Poźniak Niccolò Roda Ewout Landeloos Asier Antoranz Yannick Van Herck Amber De Visscher Philip Georg Demaerel Lukas Vanwynsberghe Jeroen Declercq Christos Gkemisis Greet Bervoets No‐Joon Song Ayse Bassez Robin Browaeys Lotte Pollaris Francesca M. Bosisio Veerle Boecxstaens Yvan Saeys Diether Lambrechts Zihai Li Patrick Matthys Oliver Bechter Jean‐Christophe Marine

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Key Points

Cytotoxic NK cells significantly impede response to checkpoint immunotherapy in melanoma, affecting treatment efficacy.
Initial immune cell clusters reveal discriminatory marker genes that influence immunotherapy outcomes.
Research employs analysis of immune cell clusters to uncover interactions with checkpoint immunotherapy.
Understanding these mechanisms may highlight crucial therapeutic avenues for improving immunotherapy in melanoma.

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Implication

Analysis shows cytotoxic NK cells impede response to checkpoint immunotherapy in melanoma, suggesting implications for treatment strategies.

Abstract

Discriminatory marker genes of initial immune cells clusters.

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Cite This Study

Poźniak et al. (2025) studied this question.

synapsesocial.com/papers/68c18c089b7b07f3a0614908 https://doi.org/10.1158/2159-8290.30050733

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplemental Table S4 from Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype2025
2Supplemental Table S3 from Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype2025
3Supplemental Table S6 from Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype2025
4Supplemental Table S11 from Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype2025
5Supplemental Table S7 from Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype2025

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Supplemental Table S5 from Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype2025
Supplemental Table S10 from Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype2025
Supplemental Table S12 from Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype2025