Supplemental Table S12 from Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype

Key Points

Cytotoxic NK cells impede the effectiveness of checkpoint immunotherapy in melanoma.
The presence of an immune-excluded phenotype correlates with lower treatment responses.
FACS analysis utilized to examine the characteristics of peripheral NK cells.
Understanding the role of NK cells may lead to new strategies for improving immunotherapy.

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Analysis identifies cytotoxic NK cells affecting response to checkpoint immunotherapy in melanoma, suggesting potential intervention strategies.

List of antibodies used for the FACS analysis of the peripheral NK cells.

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Poźniak et al. (2025) studied this question.

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