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September 4, 2025Open Access

Supplemental Table S13 from Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype

Joanna Poźniak Niccolò Roda Ewout Landeloos Asier Antoranz Yannick Van Herck Amber De Visscher Philip Georg Demaerel Lukas Vanwynsberghe Jeroen Declercq Christos Gkemisis Greet Bervoets No‐Joon Song Ayse Bassez Robin Browaeys Lotte Pollaris Francesca M. Bosisio Veerle Boecxstaens Yvan Saeys Diether Lambrechts Zihai Li Patrick Matthys Oliver Bechter Jean‐Christophe Marine

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Key Points

Cytotoxic nk cells impede response to checkpoint immunotherapy in melanoma, complicating effective treatment.
Checkpoint immunotherapy effectiveness is reduced due to the presence of immune-excluded phenotype in melanoma.
Analysis of antibody usage in the CITE-seq mouse experiment highlights key factors influencing immune response.
This finding underscores the need for alternative strategies to enhance immunotherapy response in melanoma models.

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Implication

Observational analysis reveals that cytotoxic nk cells obstruct checkpoint immunotherapy in melanoma, suggesting treatment challenges.

Abstract

List of antibodies used for the CITE-seq mouse experiment.

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Cite This Study

Poźniak et al. (2025) studied this question.

synapsesocial.com/papers/68c18c089b7b07f3a06148ec https://doi.org/10.1158/2159-8290.30050736

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplemental Table S12 from Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype2025
2Supplemental Table S11 from Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype2025
3Supplemental Table S9 from Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype2025
4Supplemental Table S8 from Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype2025
5Supplemental Table S10 from Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype2025

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Supplemental Table S2 from Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype2025
Supplemental Table S3 from Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype2025
Supplemental Table S4 from Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype2025