Supplemental Table S4 from Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype

Joanna Poźniak; Niccolò Roda; Ewout Landeloos; Asier Antoranz; Yannick Van Herck; Amber De Visscher; Philip Georg Demaerel; Lukas Vanwynsberghe; Jeroen Declercq; Christos Gkemisis; Greet Bervoets; No‐Joon Song; Ayse Bassez; Robin Browaeys; Lotte Pollaris; Francesca M. Bosisio; Veerle Boecxstaens; Yvan Saeys; Diether Lambrechts; Zihai Li; Patrick Matthys; Oliver Bechter; Jean‐Christophe Marine

doi:10.1158/2159-8290.30050727

Key Points

Cytotoxic NK cells significantly impede the response to checkpoint immunotherapy in melanoma.
The analysis focused on marker genes of myeloid cells affecting immunotherapy results.
Subclustering of myeloid cells was used to identify discriminatory markers related to immune exclusion.
These findings indicate a need for targeted strategies in melanoma with an immune-excluded phenotype.

Implication

Analysis reveals how cytotoxic NK cells impede responses to checkpoint immunotherapy in melanoma, suggesting impacts of the immune-excluded phenotype.

Abstract

Discriminatory marker genes of clusters obtained after subclustering od Myeloid cells.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Poźniak et al. (2025) studied this question.

synapsesocial.com/papers/68c18c089b7b07f3a0614a55 https://doi.org/10.1158/2159-8290.30050727

View Full Paper

Ask AI

Bookmark

Share

Supplemental Table S4 from Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplemental Table S4 from Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading