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September 4, 2025

Supplemental Table S6 from Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype

Joanna Poźniak Niccolò Roda Ewout Landeloos Asier Antoranz Yannick Van Herck Amber De Visscher Philip Georg Demaerel Lukas Vanwynsberghe Jeroen Declercq Christos Gkemisis Greet Bervoets No‐Joon Song Ayse Bassez Robin Browaeys Lotte Pollaris Francesca M. Bosisio Veerle Boecxstaens Yvan Saeys Diether Lambrechts Zihai Li Patrick Matthys Oliver Bechter Jean‐Christophe Marine

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Key Points

Cytotoxic NK cells significantly impede response to checkpoint immunotherapy in melanoma.
Study identifies specific marker genes associated with immune-excluded phenotypes in melanoma.
Subclustering of DCs and monocytes reveals distinct gene expressions linked to treatment outcomes.
Findings highlight the need for tailored approaches in immunotherapy for melanoma patients.

Implication

Research reveals how cytotoxic NK cells impede checkpoint immunotherapy in melanoma, indicating potential treatment challenges.

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Cite This Study

Poźniak et al. (2025) studied this question.

synapsesocial.com/papers/68c18c089b7b07f3a0614926 https://doi.org/10.1158/2159-8290.30050721

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplemental Table S4 from Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype2025
2Supplemental Table S3 from Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype2025
3Supplemental Table S5 from Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype2025
4Supplemental Table S2 from Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype2025
5Supplemental Table S7 from Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype2025

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Supplemental Table S11 from Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype2025
Supplemental Table S10 from Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype2025
Supplemental Table S12 from Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype2025