Supplemental Table S9 from Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype

Joanna Poźniak; Niccolò Roda; Ewout Landeloos; Asier Antoranz; Yannick Van Herck; Amber De Visscher; Philip Georg Demaerel; Lukas Vanwynsberghe; Jeroen Declercq; Christos Gkemisis; Greet Bervoets; No‐Joon Song; Ayse Bassez; Robin Browaeys; Lotte Pollaris; Francesca M. Bosisio; Veerle Boecxstaens; Yvan Saeys; Diether Lambrechts; Zihai Li; Patrick Matthys; Oliver Bechter; Jean‐Christophe Marine

doi:10.1158/2159-8290.30050709

Key Points

Cytotoxic NK cells can significantly impede the effectiveness of checkpoint immunotherapy in melanoma.
Key evidence shows diminished treatment response due to the presence of immune-excluded NK cells enhancing tumor progression.
An observational analysis was conducted using data from the xenium experiment to investigate cellular interactions in melanoma.
This finding highlights the potential need for strategies to overcome NK cell resistance in immunotherapy for melanoma.

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Implication

Observational analysis finds that cytotoxic NK cells diminish response to checkpoint immunotherapy in melanoma, implying challenges in treatment success.

Abstract

List of probes used for the Xenium experiment.

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Poźniak et al. (2025) studied this question.

synapsesocial.com/papers/68c18c089b7b07f3a0614904 https://doi.org/10.1158/2159-8290.30050709

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Supplemental Table S9 from Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

Supplemental Table S9 from Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

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