What type of study is this?

This is a Quantitative Study study.

September 17, 2025

Non-contrast free-breathing pulmonary perfusion imaging using VSASL

Key Points

Non-contrast imaging effectively measures pulmonary blood flow, with promising applications for lung assessments.
The developed velocity selective ASL technique utilizes unbalanced steady-state free-precession for imaging.
This observational study highlights a novel approach, paving the way for further evaluation in lung disease patients.
Potential implications include safer, cost-effective imaging alternatives for assessing regional pulmonary perfusion.

Abstract

Motivation: Quantitative regional pulmonary blood flow (PBF) is a diagnostically useful parameter since in the lungs regional perfusion is regulated by hypoxic pulmonary vasoconstriction. Goal(s): Due to the high costs of gadolinium-based contrast agents and safety issues contrast-free imaging technique such as arterial spin labelling (ASL) is interesting, especially for repeated measurements or applications in children. Approach: In this study, we aim to develop a robust velocity selective ASL (VSASL) sequence with unbalanced steady-state free-precession (ubSSFP)-readout for free-breathing perfusion measurement of the lung parenchyma. Results: This study shows the feasibility of non-contrast free-breathing pulmonary perfusion imaging using VSASL. Impact: This study developed a robust VSASL sequence with unbalanced steady-state free-precession (ubSSFP)-readout for free-breathing perfusion measurement of the lung parenchyma. The approach remains to be applied and examined further in patients with lung disease.

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Cite This Study

Zhang et al. (Tue,) studied this question.

synapsesocial.com/papers/68d4597031b076d99fa5c6a5 https://doi.org/https://doi.org/10.58530/2025/0910

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