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Introduction 0.05) between the group of responders and non-responders (pelargonic acid, oleic acid, lysine, hypoxanthine, heptanoic acid, 3-hydroxybutyric acid). Conclusions: At-risk adults in our sample who responded to a lifestyle intervention with significantly decreased FBG exhibited baseline differences in primary metabolism compared with those that did not respond. Findings align with our previously work in this sample characterizing the gene targets and microRNAs, which implicated novel pathways of neurodegenerative and protein misfolding disorders, as well as immune function and inflammation pathways known to be associated with T2D. Findings may help to refine target biological pathways for prevention therapies or define a subtype of participants who are best suited for lifestyle interventions to manage T2D risk. Disclosure K.A. Lewis: None. B.M. Stroebel: None. L. Zhang: None. A.M. Kanaya: None. E. Flowers: None. Funding Larry L. Hillblom Foundation (2022-D-011-FEL)
Lewis et al. (Fri,) studied this question.