June 14, 2024Diabetes

719-P: Metabolomic Characteristics Associated with Changes in Fasting Blood Glucose in a 12-Month Lifestyle Intervention Trial

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Distinct baseline metabolic profiles characterize individuals who achieve reduced fasting blood glucose following a 12-month lifestyle intervention.
Six metabolites differ at baseline with unadjusted p<0.05 between responders and non-responders across 113 plasma samples evaluated in the trial.
Analysis of stored plasma used untargeted primary metabolome profiling via liquid chromatography mass spectrometry with 15-25 internal standards.

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Implication

Randomized controlled trial finds distinct baseline primary metabolome profiles in adults reducing fasting blood glucose, suggesting targets for tailored diabetes prevention.

Cite This Study

Lewis et al. (2024) studied this question.

synapsesocial.com/papers/68e64c4eb6db6435875dd380 https://doi.org/10.2337/db24-719-p

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Implication

Randomized controlled trial finds distinct baseline primary metabolome profiles in adults reducing fasting blood glucose, suggesting targets for tailored diabetes prevention.

719-P: Metabolomic Characteristics Associated with Changes in Fasting Blood Glucose in a 12-Month Lifestyle Intervention Trial

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Discussion

Implication

Cite This Study

719-P: Metabolomic Characteristics Associated with Changes in Fasting Blood Glucose in a 12-Month Lifestyle Intervention Trial

Key Points

Discussion

Implication

Cite This Study

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