Mp51-01 a Novel Urinary Biomarker for the Detection and Surveillance of Renal Cell Carcinoma

You have accessJournal of UrologyKidney Cancer: Epidemiology & Evaluation/Staging/Surveillance II (MP51)1 May 2024MP51-01 A NOVEL URINARY BIOMARKER FOR THE DETECTION AND SURVEILLANCE OF RENAL CELL CARCINOMA Ethan Vargo, Wen C. Burns, Aleksandra Klim, Linda Black, Rebekah Keller, R. Sherburne Figenshau, and Michael Johnson Ethan VargoEthan Vargo , Wen C. BurnsWen C. Burns , Aleksandra KlimAleksandra Klim , Linda BlackLinda Black , Rebekah KellerRebekah Keller , R. Sherburne FigenshauR. Sherburne Figenshau , and Michael JohnsonMichael Johnson View All Author Informationhttps://doi.org/10.1097/01.JU.0001009492.49624.4b.01AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Effective methods of renal cell carcinoma (RCC) detection and surveillance are needed. We aimed to highlight a novel cell-specific urinary biomarker for RCC diagnosis and post-treatment follow-up. METHODS: Urine samples were collected from patients with cT1a-cT2N0M0 renal masses prior to robotic partial (RP) or robotic radical nephrectomy (RRN) and following surgery. Patient characteristics including gender, laterality, and presence of microhematuria were assessed. Samples underwent novel filtering and polymerase chain reaction testing to determine urinary tumor cell density (UTC/50 ml) (UTCD), reported as a log value (log eUTCs). Urine samples were collected at different times postoperatively and compared to preoperative levels. Postoperative characteristics including final pathology, histology, grade, presence of lymphovascular invasion, and margin status were examined. Urine samples from 10 healthy donor nephrectomy patients served as controls. Paired and unpaired t-tests were performed. RESULTS: A total of 10 patients provided a preoperative and postoperative urine sample. Nine of 10 patients underwent RPN, while one patient underwent RRN. Preoperative urinalysis was negative for microhematuria in seven of eight cases. Mean preoperative mass size was 3.8 centimeters (range 1.9-8.8 cm). Seven patients harbored clear cell RCC, one patient papillary RCC, one patient clear cell RCC with leiomyomatous features, and one patient clear cell RCC and oncocytoma. All patients had negative surgical margins. Mean preoperative UTCD in patients with renal tumors was 3.69. Eight of 10 patients experienced a significant decrease in mean postoperative UTCD to 1.94 (p=0.01) (Table 1). There was an overall uptrend in UTCD as tumor size increased, and mean UTCD increased with higher tumor grades (Figure 1). Mean UTCD of the control group was significantly lower than that of patients with renal masses preoperatively (p<0.01). CONCLUSIONS: This study demonstrates the exciting potential of a novel urinary biomarker for the diagnosis and surveillance of RCC. Download PPT Source of Funding: N/A © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e841 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Ethan Vargo More articles by this author Wen C. Burns More articles by this author Aleksandra Klim More articles by this author Linda Black More articles by this author Rebekah Keller More articles by this author R. Sherburne Figenshau More articles by this author Michael Johnson More articles by this author Expand All Advertisement PDF downloadLoading ...