Pd50-10 Free Psa and Risk of Gleason Grade Group ≥2 and Fatal Prostate Cancer in Black Men: Implications for Risk-Stratified Screening

You have accessJournal of UrologyProstate Cancer: Detection OR were 4.5(95% CI 1.9–10.9) for %fPSA 20-29%, 18.3(95% CI 7.9–42.3) for %fPSA 10–19% and 56.9(95% CI 22.5–149.9) for %fPSA <10% (Table 1). Men with a %fPSA 10-19%(OR 12.6, 95%CI 1.5 – 107.1) and <10%(OR 78.8, 95% CI 9.3–668.2) had increased risk of fatal PCa. CONCLUSIONS: In a large prospective cohort of Black men, the addition of %fPSA to tPSA improved prediction of GGG≥2 and fatal PCa. Additionally, %fPSA improved prediction across ages 40-74. %fPSA should be used to risk-stratify screening in all men to identify those at highest risk of developing GGG≥2 PCa and as a reflex test to decrease unnecessary prostate biopsies. Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e1061 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Kendrick Yim More articles by this author Chris Magnani More articles by this author Sigrid Carlsson More articles by this author Martha Shrubsole More articles by this author Kathryn Penney More articles by this author Hans Lilja More articles by this author Andrew Vickers More articles by this author Quoc Trinh More articles by this author Scott Eggener More articles by this author Lorelei Mucci More articles by this author Mark A. Preston More articles by this author Expand All Advertisement PDF downloadLoading ...