Mp10-10 Prognostic Significance of the Site of Invasion in Pt3a Renal Cell Carcinoma

You have accessJournal of UrologyKidney Cancer: Advanced (including Drug Therapy) I (MP10)1 May 2024MP10-10 PROGNOSTIC SIGNIFICANCE OF THE SITE OF INVASION IN PT3A RENAL CELL CARCINOMA Hyun Young Lee, Homin Kang, Jaeyoung Cho, Jungyo Suh, Minyong Kang, Seong Il Seo, Chang Wook Jeong, Cheol Kwak, and Cheryn Song Hyun Young LeeHyun Young Lee , Homin KangHomin Kang , Jaeyoung ChoJaeyoung Cho , Jungyo SuhJungyo Suh , Minyong KangMinyong Kang , Seong Il SeoSeong Il Seo , Chang Wook JeongChang Wook Jeong , Cheol KwakCheol Kwak , and Cheryn SongCheryn Song View All Author Informationhttps://doi.org/10.1097/01.JU.0001008588.39303.c9.10AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Pathological T3a renal cell carcinoma (RCC) encompasses three different types of locally advanced features and hence the debate on prognostic heterogeneity and need for reclassification persists. We aimed to identify the prognostic significance of the site of invasion. METHODS: Data of 1,606 patients with pT3aN0M0 RCC who underwent nephrectomy between 1990 and 2021 at three institutions were grouped according to the site of invasion: perinephric fat invasion (PFI), sinus fat invasion (SFI), renal vein invasion (RVI), PFI and SFI without RVI (PFI+SFI), and RVI with PFI and/or SFI (RVI+FI). Clinicopathological characteristics, recurrence-free (RFS) and cancer-specific survival (CSS) were compared to identify prognostic factors. Median follow-up was 58.0 months (IQR 24.1, 90.8). RESULTS: Groups with PFI+SFI, RVI and RVI+FI had significantly poorer characteristics: larger tumor size, higher nuclear grade, more frequent sarcomatoid differentiation and lymphovascular invasion. Five-year RFS were 75.8%, 66.9%, 61.7%, 60.9%, and 47.9% for SFI, PFI, PFI+SFI, RVI and RVI+FI groups, respectively (p4 cm∼≤7 cm, >7 cm), survivals were consistently poorer for the vein invasion groups compared to the fat invasion groups except for CSS among tumors ≤4 cm. Multivariate model with both the site of invasion and tumor size demonstrated superior predictive competency. CONCLUSIONS: In T3a RCC, site of invasion was an independent prognosticator of survival regardless of tumor size. Our findings may have implications for the selection of follow-up strategies and identifying optimal candidates for adjuvant therapy. Download PPTDownload PPT Source of Funding: No funding was received for this study © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e142 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Hyun Young Lee More articles by this author Homin Kang More articles by this author Jaeyoung Cho More articles by this author Jungyo Suh More articles by this author Minyong Kang More articles by this author Seong Il Seo More articles by this author Chang Wook Jeong More articles by this author Cheol Kwak More articles by this author Cheryn Song More articles by this author Expand All Advertisement PDF downloadLoading ...