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The purpose of the investigation is to develop a simple, rapid, accurate, and precise UV-Spectrophotometric method for the estimation of Vildagliptin in bulk and formulations. The validation of the developed method was carried out according to ICH guidelines concerning linearity, precision, accuracy, the limit of detection, and the limit of quantification, formulation linearity. Calibration curves were obtained in the concentration range of 5 to 30µg/ml for Vildagliptin and with good correlation coefficients (R2=0.9995). The precisions of the new method for the drug were less than the maximum allowable limit (%RSD <2.0) specified by the ICH. Therefore, the method was found to be accurate, reproducible, and sensitive for analysis of Vildagliptin in bulk and formulations.
Ramakrishna et al. (Sun,) studied this question.
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