Curcumin controls the senescence of adipose-derived mesenchymal stem cells via the FoxO3/autophagy signaling pathway to enhance joint homeostasis for osteoarthritis therapy

Key Points

• Curcumin enhances therapeutic effects in osteoarthritis by controlling senescence in stem cells, indicating its potential utility.
• The most significant mechanism observed was autophagy regulation linked to FoxO3 signaling affecting stem cell behavior.
• Assessment using curcumin-pretreated adipose-derived mesenchymal stem cells delivered via intra-articular injection for joint health.
• This highlights curcumin's potential in osteoarthritis treatment but calls for further studies on clinical efficacy.