Early aortic valve replacement reduced the risk of all-cause death by 57% compared to medical observation in patients with moderate aortic stenosis and left ventricular systolic dysfunction.
Cohort (n=255)
No
Does early surgical aortic valve replacement reduce all-cause death in patients with moderate aortic stenosis and left ventricular systolic dysfunction?
Early surgical aortic valve replacement in patients with moderate aortic stenosis and left ventricular systolic dysfunction is associated with a significantly lower risk of all-cause mortality compared to medical observation.
Effect estimate: HR 0.43 (95% CI 0.20–0.91)
Absolute Event Rate: 5.03% vs 18.8%
p-value: p=0.028
In patients with moderate AS and LVSD, AVR reduces the risk of all-cause death. A prospective randomized trial is warranted to confirm our findings.
Moon et al. (Wed,) conducted a cohort in Moderate aortic stenosis and left ventricular systolic dysfunction (n=255). Aortic valve replacement (AVR) vs. Medical observation (no AVR) was evaluated on All-cause death (HR 0.43, 95% CI 0.20–0.91, p=0.028). Early aortic valve replacement reduced the risk of all-cause death by 57% compared to medical observation in patients with moderate aortic stenosis and left ventricular systolic dysfunction.