Abstract Objective Deuterium metabolic imaging (DMI) is an emerging MR technique providing non-invasive insights into glucose metabolism. Reliable concentration estimation depends on knowledge of tissue specific relaxation times. This study reports T ₁ and T ₂ relaxation time constants of deuterium-labeled water (HDO) and glucose (Glc) from the human liver and kidney at 7T. Materials and methods Twelve healthy volunteers (6f/6 m) were examined using k -space-reordered inversion-recovery and spin-echo DMI with non-Cartesian concentric-ring trajectory (CRT) sampling. Seven volunteers underwent oral 2 H-Glc (0.8 g/kg body weight) administration. Data were averaged over organ-specific masks before spectral fitting. One volunteer was measured after oral D₂O (0.5 ml/kg body weight) administration. Results Faster longitudinal relaxation but similar transversal relaxation were observed for 2 H-labeled Glc in the liver compared to kidney tissue ( T ₁ liver/kidney = 60 ± 4 ms/85 ± 18 ms, p = 0.016; T ₂ liver/kidney = 31 ± 6 ms/35 ± 2 ms, p = 0.283). HDO exhibited significantly shorter liver relaxation times ( T 1 liver/kidney = 218 ± 24 ms/324 ± 34 ms, p < 0.001; T ₂ liver/kidney = 28 ± 4 ms/39 ± 6 ms, p < 0.001). D₂O loading improved voxelwise SNR enabling renal T ₁/ T ₂ mapping of HDO. Discussion Hepatic and renal glucose homeostasis is often impaired in several pathophysiological conditions such as tumors, diabetes and metabolic dysfunction-associated steatotic liver disease. Using organ-specific 2 H relaxation times increases the accuracy of concentration estimation and can help to improve the understanding of underlying metabolic processes in future abdominal DMI studies, which can help to push abdominal DMI towards clinical application.
Bader et al. (Fri,) studied this question.
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