Lactate promotes cuproptosis in acute kidney injury by activating H3K18 lactylation-dependent upregulation of HSPA6 expression

Key Points

• This research aims to uncover the epigenetic mechanisms by which lactate influences kidney damage in acute kidney injury.
• Investigation of lactate's role in AKI
• Analysis of H3K18 lactylation levels
• Assessment of HSPA6 expression
• Evaluation of cuproptosis markers
• Lactate triggers H3K18 lactylation, enhancing HSPA6 expression
• Cuproptosis is promoted, leading to increased renal damage
• The lactate-H3K18la-HSPA6 pathway presents a new therapeutic target for AKI