Chlorthalidone reduced 24-h ambulatory systolic blood pressure by 4.21 mmHg and diastolic BP by 2.23 mmHg more effectively than hydrochlorothiazide without significantly increasing hypokalaemia risk.
Does chlorthalidone reduce blood pressure more effectively than hydrochlorothiazide in patients with hypertension?
Chlorthalidone lowers systolic and diastolic blood pressure more effectively than hydrochlorothiazide without significantly increasing the risk of hypokalaemia, supporting its use as the more efficacious thiazide option.
Absolute Event Rate: 0% vs 0%
Background both P < 0.01). Office systolic BP was also lower with chlorthalidone (MD: –4.10 mmHg, 95% CI –6.11 to –2.08; P < 0.01), whereas office diastolic BP showed no significant difference (MD: –1.70 mmHg, 95% CI –3.40 to 0; P = 0.05). The risk of hypokalaemia did not differ significantly (RR: 1.51, 95% CI 0.83–2.72; P = 0.17). Hypokalaemia was numerically more frequent with chlorthalidone. Interpretation & conclusions Chlorthalidone lowers systolic and diastolic BP more effectively than hydrochlorothiazide without significantly increasing the risk of hypokalaemia. These findings support chlorthalidone as the more efficacious thiazide option, particularly where cost-effective BP control is critical. Larger, long-term RCTs are needed to determine whether these BP benefits translate into superior cardiovascular outcomes.
Aggarwal et al. (Sat,) reported a other. Chlorthalidone reduced 24-h ambulatory systolic blood pressure by 4.21 mmHg and diastolic BP by 2.23 mmHg more effectively than hydrochlorothiazide without significantly increasing hypokalaemia risk.
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