What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Hypertension (n=2998). Intervention: Triglyceride glucose-body mass index (TyG-BMI) vs. Lowest quartile of TyG-BMI (Q1). Primary outcome: Odds Ratio of hypertension (OR 2.463, 95% CI (1.794–3.382), p=<0.001).

What does this research mean for the field?

The TyG-BMI index is associated with a higher risk of hypertension among rural adults in southwest China, with an adjusted odds ratio of 2.463 for the highest quartile compared to the lowest quartile. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

What question did this study set out to answer?

This study investigates the association between the triglyceride-glucose body mass index and hypertension in adults from rural southwest China.

February 5, 2026Frontiers in Cardiovascular Medicine0 citationsOpen Access

The triglyceride glucose-body mass index is positively associated with higher risk of hypertension in rural southwest Chinese population: a cross sectional study

Q: What are the key findings of this study?

The TyG-BMI index was associated with a higher risk of hypertension, with an adjusted OR of 2.463 for the highest quartile compared to the lowest quartile.

Q: What does this research mean for the field?

The TyG-BMI index is associated with a higher risk of hypertension among rural adults in southwest China, with an adjusted odds ratio of 2.463 for the highest quartile compared to the lowest quartile. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

Q: What question did this study set out to answer?

This study investigates the association between the triglyceride-glucose body mass index and hypertension in adults from rural southwest China.

MDMingxue DongThe First People's Hospital of Shunde MMMing MaThe First People's Hospital of Shunde LYLiJing YangThe First People's Hospital of Shunde

Key Result

The TyG-BMI index was associated with a higher risk of hypertension, with an adjusted OR of 2.463 for the highest quartile compared to the lowest quartile.

Key Points

This study investigates the association between the triglyceride-glucose body mass index and hypertension in adults from rural southwest China.
Cross-sectional study design
Inclusion of 2,998 adults aged 30-79
Logistic regression and receiver operating characteristic analysis
Subgroup and sensitivity analyses applied
Hypertension prevalence was 39.93% among participants
Increased odds ratios (ORs) for hypertension were noted in higher TyG-BMI quartiles
TyG-BMI index had a 64.1% ability to distinguish hypertension
Nonlinear association between TyG-BMI and hypertension was established

Study Design

Type

Cross-Sectional (n=2,998)

Multicenter

Structured PICO

Is a higher triglyceride glucose-body mass index (TyG-BMI) associated with an increased risk of hypertension in rural southwest Chinese adults?

Population

2,998 adults (aged 30 to 79 years, Han ethnicity) from rural southwest China (Rongchang, Chongqing municipality), median age 49, 49.97% male.

Intervention

Higher quartiles (Q2, Q3, Q4) of the triglyceride glucose-body mass index (TyG-BMI)

Comparator

Lowest quartile (Q1) of the triglyceride glucose-body mass index (TyG-BMI <20.69)

Outcome

Prevalence of hypertension

The TyG-BMI index is a useful surrogate marker for insulin resistance that is independently and nonlinearly associated with a higher risk of hypertension in rural Chinese adults.

Main Result

Effect estimate: OR 2.463 (95% CI (1.794–3.382))

p-value: p=<0.001

Limitations

Cross-sectional design limits causality inference.
Study population restricted to rural southwest China may limit generalizability.
Potential bias due to participants being aware of their hypertension status.

Abstract

Background Insulin resistance (IR) has been shown to be associated with hypertension. The triglyceride-glucose body mass index (TyG-BMI) has emerged as a novel surrogate marker for assessing IR. This study aimed to investigate the association between the TyG-BMI index and hypertension among adults in rural southwest China using a cross-sectional study. Method We recruited 2,998 people between the ages of 30 and 79 from Rongchang, Chongqing municipality, southwest China, as part of The China Multi-Ethnic Cohort Study, considered the largest cohort study in southwest China. Logistic regression model, restricted cubic spline (RCS) model and receiver operating characteristic (ROC) were applied to estimate the association between the TyG-BMI index and hypertension. Moreover, subgroup and sensitivity analyses were undertaken to check the consistency of the outcomes. Results A total of 2,998 participants were included in the present study, with a hypertension prevalence of 39.93%. After adjusting for confounding factors, the ORs of hypertension in Q2, Q3, Q4 were 1.641 (1.277–2.109), 1.768 (1.371–2.281), 2.463 (1.794–3.382) compared with the lowest quartile (Q1), respectively. RCS indicated that the TyG-BMI index was nonlinearly associated with hypertension ( P for overall 0.001, P for nonlinea r = 0.046). The ROC analysis indicated that the TyG-BMI index had a 64.1% (AUC: 0.641, 95% CI: 0.621–0.661) ability to distinguish hypertension. Subgroup analysis in participants without diabetes, dyslipidemia, hyperuricemia and central obesity as well as sensitivity analyses also demonstrated the similar relationship between the TyG-BMI index and hypertension. Conclusion The current study demonstrates that the TyG-BMI index is associated with higher risk of hypertension among rural adults in southwest China. Lifestyle modifications, including weight control, vigorous physical activity and healthy dietary pattern can help improve IR and prevent hypertension.

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