Why the study?
Insulin resistance is associated with hypertension, and the triglyceride-glucose body mass index (TyG-BMI) has emerged as a novel surrogate marker for it, but its association with hypertension in rural southwest China needed investigation.
Is a higher triglyceride glucose-body mass index (TyG-BMI) associated with an increased risk of hypertension in rural southwest Chinese adults?
Cross-Sectional (n=2,998)
No
Is a higher triglyceride glucose-body mass index (TyG-BMI) associated with an increased risk of hypertension in rural southwest Chinese adults?
Effect estimate: OR 2.463 (95% CI (1.794–3.382))
p-value: p=<0.001
The TyG-BMI index is a useful surrogate marker for insulin resistance that is independently and nonlinearly associated with a higher risk of hypertension in rural Chinese adults.
TyG-BMI may flag higher hypertension risk in rural Chinese adults; supports consensus on insulin resistance link but leaves causal role open.
Background Insulin resistance (IR) has been shown to be associated with hypertension. The triglyceride-glucose body mass index (TyG-BMI) has emerged as a novel surrogate marker for assessing IR. This study aimed to investigate the association between the TyG-BMI index and hypertension among adults in rural southwest China using a cross-sectional study. Method We recruited 2,998 people between the ages of 30 and 79 from Rongchang, Chongqing municipality, southwest China, as part of The China Multi-Ethnic Cohort Study, considered the largest cohort study in southwest China. Logistic regression model, restricted cubic spline (RCS) model and receiver operating characteristic (ROC) were applied to estimate the association between the TyG-BMI index and hypertension. Moreover, subgroup and sensitivity analyses were undertaken to check the consistency of the outcomes. Results A total of 2,998 participants were included in the present study, with a hypertension prevalence of 39.93%. After adjusting for confounding factors, the ORs of hypertension in Q2, Q3, Q4 were 1.641 (1.277–2.109), 1.768 (1.371–2.281), 2.463 (1.794–3.382) compared with the lowest quartile (Q1), respectively. RCS indicated that the TyG-BMI index was nonlinearly associated with hypertension ( P for overall < 0.001, P for nonlinea r = 0.046). The ROC analysis indicated that the TyG-BMI index had a 64.1% (AUC: 0.641, 95% CI: 0.621–0.661) ability to distinguish hypertension. Subgroup analysis in participants without diabetes, dyslipidemia, hyperuricemia and central obesity as well as sensitivity analyses also demonstrated the similar relationship between the TyG-BMI index and hypertension. Conclusion The current study demonstrates that the TyG-BMI index is associated with higher risk of hypertension among rural adults in southwest China. Lifestyle modifications, including weight control, vigorous physical activity and healthy dietary pattern can help improve IR and prevent hypertension.
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Dong et al. (2026) conducted a cross-sectional in Hypertension (n=2,998). Triglyceride glucose-body mass index (TyG-BMI) vs. Lowest quartile of TyG-BMI (Q1) was evaluated on Odds Ratio of hypertension (OR 2.463, 95% CI (1.794–3.382), p=<0.001).
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