Mechanochemical synthesis of drug-drug eutectics of the anthelmintic drug, praziquantel, with NSAIDs

Key Points

• The aim is to develop drug-drug eutectics of praziquantel with NSAIDs to enhance their solubility and stability.
• Utilization of mechanochemical synthesis techniques
• Combining praziquantel with various NSAIDs
• Characterization of eutectic systems
• Evaluation of solubility and dissolution rate
• Eutectics showed significantly increased solubility compared to individual drugs
• Enhanced dissolution rates were observed in the synthesized formulations
• Stability of the drug compounds was improved in eutectic form