Mechanochemical synthesis of drug-drug eutectics of the anthelmintic drug, praziquantel, with NSAIDs

Nitha Sadanandan; Abhina Mandodi; Cinu Winson; Indira S. Divya; Sunil Varughese

doi:10.1039/d5ce01149c

January 1, 2026CrystEngComm

Mechanochemical synthesis of drug-drug eutectics of the anthelmintic drug, praziquantel, with NSAIDs

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Key Points

The aim is to develop drug-drug eutectics of praziquantel with NSAIDs to enhance their solubility and stability.
Utilization of mechanochemical synthesis techniques
Combining praziquantel with various NSAIDs
Characterization of eutectic systems
Evaluation of solubility and dissolution rate
Eutectics showed significantly increased solubility compared to individual drugs
Enhanced dissolution rates were observed in the synthesized formulations
Stability of the drug compounds was improved in eutectic form

Implication

This research demonstrates enhanced solubility and stability of drug-drug eutectics in pharmaceuticals, suggesting improved drug effectiveness.

Abstract

Eutectic systems offer a crystalline, thermodynamically favourable route to enhance solubility, dissolution rate, and stability of poorly soluble pharmaceuticals. Here, we report the mechanochemical synthesis of four drug-drug eutectics of...

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Cite This Study

Sadanandan et al. (2026) studied this question.

synapsesocial.com/papers/698828990fc35cd7a884841c https://doi.org/10.1039/d5ce01149c

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Mechanochemical synthesis of drug-drug eutectics of the anthelmintic drug, praziquantel, with NSAIDs

Key Points

Implication

Abstract

Discussion

Cite This Study

Mechanochemical synthesis of drug-drug eutectics of the anthelmintic drug, praziquantel, with NSAIDs

Key Points

Implication

Abstract

Discussion

Cite This Study

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