A Comprehensive Meta-Analysis of Exogenous Estrogen, Progesterone, and Testosterone in Animal Models of Ischemic and Hemorrhagic Stroke

Key Points

• To assess the impact of exogenous estrogen, progesterone, and testosterone on ischemic and hemorrhagic stroke in animal studies.
• Conducted a meta-analysis of existing studies on hormone treatment in stroke models.
• Included both ischemic and hemorrhagic stroke animal models.
• Analyzed the effects of each hormone on stroke outcomes.
• Exogenous estrogen showed a significant protective effect against ischemic stroke.
• Progesterone appeared to have a moderate impact on reducing hemorrhagic stroke damage.
• Testosterone's effects were less consistent across studies.