What question did this study set out to answer?

The research aims to investigate the connection between maternal adiposity and epigenetic modifications in iron metabolism genes during early pregnancy.

February 9, 2026Open Access

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Maternal adiposity and DNA methylation of TfR2 and HJV genes in early pregnancy: mediating role of inflammation and consequences for iron status

SDSabrina P. DemirdjianUniversity of Ulster RIRachelle E IrwinUniversity of Ulster PTPaul D. ThompsonUniversity of Ulster

Key Points

The research aims to investigate the connection between maternal adiposity and epigenetic modifications in iron metabolism genes during early pregnancy.
Analyzed DNA methylation levels of TfR2 and HJV genes in maternal samples
Measured inflammation markers related to maternal adiposity
Evaluated iron status of mothers in early pregnancy
Increased maternal adiposity correlated with altered DNA methylation patterns in TfR2 and HJV genes
Inflammation acted as a mediator in the relationship between adiposity and gene methylation
Changes in gene methylation were associated with variations in maternal iron status

Abstract

Maternal adiposity is associated with epigenetic changes in the iron metabolism genes TfR2 and HJV in early pregnancy, part of which are inflammation-mediated changes in HJV.

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Maternal adiposity and DNA methylation of TfR2 and HJV genes in early pregnancy: mediating role of inflammation and consequences for iron status

Key Points

Abstract

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