Regioselective House–Meinwald Rearrangement in Oxindoles: Access to Substituted Quinolinones

Key Points

• The aim is to investigate the regioselective House–Meinwald rearrangement of oxindoles to produce quinolinones.
• Utilized oxindole substrates in the rearrangement
• Conducted reactions under EBHP and base-mediated conditions
• Applied epoxidation as a key step in synthesis
• Successfully synthesized 3-substituted 4-hydroxyquinoline-2-ones
• Produced quinoline-2,4-diones
• Demonstrated efficiency in a one-pot reaction process