What question did this study set out to answer?

The aim is to investigate the regioselective House–Meinwald rearrangement of oxindoles to produce quinolinones.

February 14, 2026Organic & Biomolecular Chemistry1 citations

Regioselective House–Meinwald Rearrangement in Oxindoles: Access to Substituted Quinolinones

BMB. Mohan KSK. S. SandhyaUniversity of Kerala RTRamakrishnan ThusharaNational Institute for Interdisciplinary Science and Technology

Key Points

The aim is to investigate the regioselective House–Meinwald rearrangement of oxindoles to produce quinolinones.
Utilized oxindole substrates in the rearrangement
Conducted reactions under EBHP and base-mediated conditions
Applied epoxidation as a key step in synthesis
Successfully synthesized 3-substituted 4-hydroxyquinoline-2-ones
Produced quinoline-2,4-diones
Demonstrated efficiency in a one-pot reaction process

Abstract

House–Meinwald rearrangement of oxindole substrates facilitates a one-pot synthesis of 3-substituted 4-hydroxyquinoline-2-ones and quinoline-2,4-diones under EBHP and base-mediated conditions is reported. This transformation proceeds through a well-defined sequence involving epoxidation,...

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