Synthesis, characterisation and biological properties of a silver helicate which displays enhanced activity towards methicillin-resistant Staphylococcus aureus (MRSA)

Key Points

• Investigate the synthesis and biological properties of a silver helicate, focusing on its antimicrobial effects.
• Synthesis of a dinuclear silver helicate
• Characterisation of its structure and properties
• Assessment of cytotoxicity against cancer cell lines
• Evaluation of antimicrobial activity against various bacteria, including MRSA
• The silver helicate exhibited significant cytotoxic effects on cancer cell lines.
• Enhanced antimicrobial activity was observed against MRSA compared to traditional silver cations.
• MRSA was more sensitive to the silver helicate than other tested bacteria, E. coli and P. aeruginosa.