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Uptake of an automated de-factoring option for EQA result submissions | Synapse

February 22, 2026

Uptake of an automated de-factoring option for EQA result submissions

Key Points

To investigate the effects of automated de-factoring on EQA result submissions and reference intervals.
Assessment of automated de-factoring option in clinical laboratories
Analysis of submission practices regarding EQA results
Evaluation of the impact on quantitative results and reference intervals.
Identified challenges posed by PACF in EQA evaluations
Highlighted the importance of de-factoring before result submission
Indicated potential improvements in EQA accuracy through automation.

Abstract

Background: Clinical Laboratories may apply a post-analytical correction factor (PACF) to their quantitative results to align different methods or avoid changes to established reference intervals due to variation in reagent/calibrator lots. These factors may, in turn, create problems for EQA providers when evaluating EQA results that were not de-factored before submission.

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Cite This Study

Peter Graham (Sun,) studied this question.

synapsesocial.com/papers/699a534bfdaf4e3c1268ee05 https://doi.org/https://doi.org/10.1016/j.pathol.2026.01.159

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