Analysis indicates the automated de-factoring option affects reference intervals in clinical laboratories, suggesting improvements for EQA accuracy.
Background: Clinical Laboratories may apply a post-analytical correction factor (PACF) to their quantitative results to align different methods or avoid changes to established reference intervals due to variation in reagent/calibrator lots. These factors may, in turn, create problems for EQA providers when evaluating EQA results that were not de-factored before submission.
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Peter Graham (2026) studied this question.
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