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Examine the therapeutic potential of short-chain fatty acids and gut microbiota in spinal cord injury recovery.

February 22, 2026Open Access

The role of short-chain fatty acids in spinal cord injury: A systematic review of human and animal evidence

Key Points

Examine the therapeutic potential of short-chain fatty acids and gut microbiota in spinal cord injury recovery.
Systematic review of existing human and animal studies
Analysis of the role of short-chain fatty acids in recovery mechanisms
Evaluation of gut microbiota's impact on spinal cord injury outcomes
Promising results noted in animal models regarding SCFAs
Limited evidence found from human studies on SCFA effectiveness
Highlights a need for further human-based research on gut microbiota and SCFAs

Abstract

This review highlights the potential of targeting the gut microbiota and SCFAs as therapeutic strategies for SCI recovery. However, despite promising results in animal models, human evidence remains limited.

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