Feasibility Trial of Prolonged versus Single-Dose Challenge in Penicillin Allergy

Key Points

• The aim is to evaluate the feasibility of a prolonged multi-dose oral amoxicillin challenge compared to a single dose in individuals with penicillin allergy.
• Conducted a double-blind, placebo-controlled randomized trial
• Compared single-dose versus multidose oral amoxicillin challenge
• Involved participants with penicillin allergy
• Demonstrated feasibility of conducting the trial
• Found that a fully powered efficacy trial is necessary to assess between-group differences in adverse events