Feasibility trial investigates immune-mediated adverse events in penicillin allergy, indicating a need for further research.
Conducting a double-blind, placebo-controlled randomized trial of single-dose versus multidose oral amoxicillin challenge was feasible. A fully powered efficacy trial is needed to assess between-group differences in immune-mediated adverse events. (Funded by Austin Health and others; trial registration: ANZCTR - ACTRN12623001242617, registered on November 30, 2023.).
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Rose et al. (2026) studied this question.
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