International multicenter study evaluates direct oral challenge for penicillin allergy, showing feasibility and safety.
In this international, multicenter prospective study, implementing penicillin direct oral challenge (DOC) using a digital toolkit was acceptable, feasible, and sustainable. Audit and feedback increased activity, particularly among pharmacists. Safety was maintained across heterogeneous DOC protocols, validating a pragmatic, scalable approach that supports local adaptation.
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Mitri et al. (2026) studied this question.
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