MDSGene Systematic Review of Common Forms of Dominant Hereditary Spastic Paraplegia: Novel Insights.

Key Points

• To systematically review common forms of dominant hereditary spastic paraplegia and model disease progression.
• Conducted a systematic review of existing literature on hereditary spastic paraplegia.
• Compared clinical phenotypes of HSP-ATL1, HSP-SPAST, and HSP-REEP1.
• Modeled longitudinal progression using SPRS scores.
• Identified notable differences in clinical phenotypes among HSP-ATL1, HSP-SPAST, and HSP-REEP1.
• Noted the challenge of missing data impacting comparisons.
• Emphasized the necessity for uniform data collection protocols.