MDSGene Systematic Review of Common Forms of Dominant Hereditary Spastic Paraplegia: Novel Insights.

Q: What does this research mean for the field?

HSP-ATL1, HSP-SPAST, and HSP-REEP1 exhibit distinct clinical phenotypes in hereditary spastic paraplegia. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

Ce Kang; Rajasumi Rajalingam; Zachary F. Walls; Jana Huang; Christine Sun; Laura Ivete Rudaks; Dennis Yeow; Ashar Rasheed; J. Zhang; Moath Hamed; Marianthi Breza; Susen Schaake; Chetan Vekhande; Jason Massa; Robyn E Massa; Aakash Shetty; Carolyn M. Sue; Franca Cambi; Oksana Suchowersky; Franca Vulinović; Sonja Petkovic; Christine Klein; Katja Lohmann; Connie Marras; Kishore R Kumar

doi:10.1002/mdc3.70559

Key Points

To systematically review common forms of dominant hereditary spastic paraplegia and model disease progression.
Conducted a systematic review of existing literature on hereditary spastic paraplegia.
Compared clinical phenotypes of HSP-ATL1, HSP-SPAST, and HSP-REEP1.
Modeled longitudinal progression using SPRS scores.
Identified notable differences in clinical phenotypes among HSP-ATL1, HSP-SPAST, and HSP-REEP1.
Noted the challenge of missing data impacting comparisons.
Emphasized the necessity for uniform data collection protocols.

Implication

Systematic review reveals differences in clinical phenotypes of hereditary spastic paraplegia, suggesting a need for standardized data collection.

Abstract

Overall, HSP-ATL1, HSP-SPAST and HSP-REEP1 demonstrated differences in clinical phenotypes. To our knowledge, this is the first systematic review to model longitudinal progression using SPRS scores in HSP. Missing data is a limiting factor in all these comparisons, highlighting the need for uniform data collection. Online resources can be found at https://www.mdsgene.org/.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Kang et al. (2026) studied this question.

synapsesocial.com/papers/69a13550ed1d949a99abf0d2 https://doi.org/10.1002/mdc3.70559

View at Publisher

Ask AI

Bookmark

Share

MDSGene Systematic Review of Common Forms of Dominant Hereditary Spastic Paraplegia: Novel Insights.

Key Points

Implication

Abstract

Discussion

Cite This Study

MDSGene Systematic Review of Common Forms of Dominant Hereditary Spastic Paraplegia: Novel Insights.

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading