Network-targeted TMS modulates nicotine craving and default mode network connectivity in psychotic disorders | Synapse
March 2, 2026Open Access
Network-targeted TMS modulates nicotine craving and default mode network connectivity in psychotic disorders
Key Points
The aim is to explore the relationship between nicotine use, craving, and psychosis, and to identify a novel intervention target.
Utilized network-targeted transcranial magnetic stimulation (TMS)
Examined its effects on nicotine craving
Analyzed default mode network connectivity in participants with psychotic disorders
Engaging the network target significantly reduced nicotine craving
Altered default mode network connectivity was observed
Supports the idea of using TMS as an intervention for nicotine use in psychosis
Abstract
We identified a potential mechanism of nicotine use in psychosis and demonstrated that engaging this target reduces craving, suggesting a novel target for nicotine interventions in psychosis.