Clinical performance of an IGF1 LC-MS/MS assay and associated normative dataset in routine endocrinology.

Key Points

• To evaluate the clinical performance of an IGF1 LC-MS/MS assay and its normative dataset.
• Utilized a population-based normative dataset for IGF1 levels.
• Compared results with traditional ligand-binding assay (LBA) methods.
• Conducted clinical assessments to determine alignment of results.
• Demonstrated superior alignment of the LC-MS/MS assay with clinical assessments over LBA.
• Established the IGF1 method as a reliable benchmark for IGF1 interpretation.
• Facilitated the potential for broader adoption of the Lifelines normative dataset.