circ-UBR5 in hypoxia-induced exosomes may mediate lung adenocarcinoma metastasis via the targeting of HNRNPR

Key Points

• High levels of circ-UBR5 and HNRNPR correlate with poor prognosis in lung adenocarcinoma patients, emphasizing their clinical importance.
• The circ-UBR5-HNRNPR axis significantly drives the metastatic potential of normoxic lung adenocarcinoma cells.
• Observation reveals that circ-UBR5 from hypoxic cells is delivered to normoxic cells through exosomes, impacting metastatic behavior.
• These findings suggest that circ-UBR5 and HNRNPR could serve as promising therapeutic targets in lung cancer treatment.