Prolyl 4-Hydroxylase Beta Peptide Promotes Invasion, Migration, and Epithelial-Mesenchymal Transition through Activation of the Claudin-1/ AMPK/TGF-β1 Pathway in Bladder Cancer Cells

Key Points

• Invasion and migration of bladder cancer cells increased significantly after P4HB activation, indicating a strong pathway influence.
• Key evidence includes alterations in Claudin-1, AMPK, and TGF-β1, which are critical in promoting epithelial-mesenchymal transition (EMT).
• Analysis reveals activation of the Claudin-1/AMPK/TGF-β1 pathway through P4HB, crucial for cancer cell behavior and progression.
• This finding supports the notion that targeting these molecular pathways may provide new treatment strategies for cancer patients, especially in advanced stages.

Abstract