Polyphenols from the aerial parts of Lespedeza cuneata and their inhibitory effects on PTP1B and α-glucosidase: insights from in vitro and in Silico analyses | Synapse
March 3, 2026
Polyphenols from the aerial parts of Lespedeza cuneata and their inhibitory effects on PTP1B and α-glucosidase: insights from in vitro and in Silico analyses
Key Points
Polyphenols exhibited significant inhibitory effects on PTP1B and alpha-glucosidase, indicating potential for diabetes management.
The analysis revealed over 70% inhibition of alpha-glucosidase at optimal polyphenol concentrations during assays.
In vitro experiments were complemented with in silico molecular docking studies to assess binding affinities.
Findings may enable future therapeutic strategies targeting PTP1B and alpha-glucosidase in metabolic disorders.