Schisandrol A induces cardiac developmental toxicity in zebrafish (Danio rerio) via disruption of calcium homeostasis, oxidative stress, and apoptosis | Synapse
March 3, 2026
Schisandrol A induces cardiac developmental toxicity in zebrafish (Danio rerio) via disruption of calcium homeostasis, oxidative stress, and apoptosis
Key Points
Cardiac developmental toxicity is evident following exposure to Schisandrol A, showing significant harm to heart formation.
In zebrafish models, disruption of calcium homeostasis, oxidative stress, and apoptosis are key factors identified.
Assessment using zebrafish as a model organism reveals how Schisandrol A disrupts normal heart development processes.
These findings highlight potential risks associated with Schisandrol A, emphasizing the need for caution in its use.