Decoding the Mechanisms of Hepatocellular Carcinoma Cancer Stem Cells and Identifying Potential Therapeutic Strategies Based on Single-cell Omics

Key Points

• The aim is to understand the mechanisms of cancer stem cells in hepatocellular carcinoma and identify therapeutic strategies.
• Created a single-cell atlas of cancer stem cells in hepatocellular carcinoma
• Analyzed spatial niches and regulatory programs
• Identified prognostic signatures and potential candidate drugs
• Highlighted the spatial niches of cancer stem cells in HCC
• Established a prognostic signature for predicting outcomes
• Identified candidate drugs that may target cancer stem cells effectively