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March 1, 2026Cancer Genomics & ProteomicsOpen Access

Decoding the Mechanisms of Hepatocellular Carcinoma Cancer Stem Cells and Identifying Potential Therapeutic Strategies Based on Single-cell Omics

Xiaotian Tan Qiaoxian Luo YING GE NING DENG PING JIN MENGHUAN SONG CAROLINA OI LAM UNG Meiwan Chen Hao Hu

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Key Points

The aim is to understand the mechanisms of cancer stem cells in hepatocellular carcinoma and identify therapeutic strategies.
Created a single-cell atlas of cancer stem cells in hepatocellular carcinoma
Analyzed spatial niches and regulatory programs
Identified prognostic signatures and potential candidate drugs
Highlighted the spatial niches of cancer stem cells in HCC
Established a prognostic signature for predicting outcomes
Identified candidate drugs that may target cancer stem cells effectively

Implication

Uncovers mechanisms of cancer stem cells in hepatocellular carcinoma, indicating potential therapeutic targets.

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Cite This Study

Tan et al. (2026) studied this question.

synapsesocial.com/papers/69a91cbed6127c7a504bfb6a https://doi.org/10.21873/cgp.20577

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Construction of a Prognostic and Diagnostic Gene Signature Based on the Characteristics of Cancer Stem‐Like Cells for the Treatment Guidance of Hepatocellular CarcinomaOriginal Research · 2026
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5Cancer stem cells in cholangiocarcinoma: emerging roles as therapeutic targets2025