What does this research mean for the field?

ACC-iTBS TMS with the H1 coil is a safe and time-efficient alternative to standard HF H1-coil TMS, providing comparable outcomes and faster remission in patients with depression. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

What question did this study set out to answer?

To compare the effectiveness of accelerated TMS with the H1-coil against standard HF TMS for treating depression.

March 7, 2026Brain stimulation4 citationsOpen Access

Accelerated TMS with the H1-coil for Depression: A Multisite, Randomized Non-Inferiority Trial

CHColleen A. HanlonWake Forest University YRYiftach RothBen-Gurion University of the Negev RBRichard A. BermudesZephyr Software (United States)

Key Points

To compare the effectiveness of accelerated TMS with the H1-coil against standard HF TMS for treating depression.
Conducted a multisite, randomized, non-inferiority trial
Participants received either accelerated TMS or standard HF TMS
Measured outcomes focused on remission rates and treatment tolerability
Accelerated TMS shows outcomes comparable to standard HF TMS
Both treatment methods proved safe and well-tolerated
Faster remission observed with accelerated TMS

Abstract

ACC-iTBS TMS with the H1 coil is a safe, well-tolerated, and time-efficient alternative to standard HF H1-coil TMS, offering comparable outcomes and faster remission.

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