Molecular Mechanisms of FAT Atypical Cadherin 1 (FAT1), the Hippo Pathway, and the Yes-Associated Protein (YAP) Signaling Pathways in Some Cancers | Synapse
March 10, 2026Open Access
Molecular Mechanisms of FAT Atypical Cadherin 1 (FAT1), the Hippo Pathway, and the Yes-Associated Protein (YAP) Signaling Pathways in Some Cancers
Key Points
The central aim is to explore the roles of FAT1, Hippo, and YAP pathways in cancer through mutations and expression changes.
Review of existing literature on FAT1, Hippo, and YAP gene functions.
Analysis of the impact of mutations on signaling mechanisms in cancer types.
Discussion of expression levels in relation to tumor behavior.
FAT1 mutations are linked to altered signaling pathways in specific cancers.
Hippo pathway dysfunction contributes to cancer progression through YAP activation.
Dysregulation of gene expression in these pathways promotes tumor formation.
Abstract
This review discusses the FAT1, Hippo and Yap genes, with a focus on their mutations and expression levels, and their impact on signaling pathways and mechanisms in various types of cancer.