Risk of Breast and Ovarian Cancer After Prophylactic Mastectomy and Salpingo‐Oophorectomy in BRCA1 /2 Germline Variant Carriers: A Retrospective Cohort Study From a Single German Center

Key Points

• The study aims to evaluate the effectiveness of prophylactic surgeries in reducing cancer risk for BRCA1/2 variant carriers.
• Conducted a retrospective cohort study at a single German center.
• Assessed outcomes of prophylactic mastectomy and salpingo-oophorectomy.
• Compared ipsilateral cancer prevalence between mastectomy and breast-sparing surgery.
• Prophylactic surgeries showed high oncological effectiveness in germline variant carriers.
• Mastectomy provided greater protection against ipsilateral cancer compared to breast-conserving surgery.
• Further studies are needed to explore cancer prevalence differences.