Pkm2 modified RNA shows therapeutic potential as a gene delivery platform to promote cardiac regeneration by regulating the cardiomyocyte cell cycle.
We demonstrate that Pkm2 is an important intrinsic regulator of the cardiomyocyte cell cycle and oxidative stress, and highlight its therapeutic potential using cardiomyocyte-specific Pkm2 modified RNA as a gene delivery platform.
Magadum et al. (Tue,) studied this question.
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