Visible‐Light Mediated Functionalization in Phe‐Containing Peptides Upon a Debenzylative Amination Process

Key Points

• The central aim is to develop an efficient method for modifying phenylalanine-containing peptides.
• Utilized a tandem debenzylation-amination process.
• Applied N-iodoimides in the reaction.
• Conducted under visible-light irradiation.
• Performed in metal-free conditions.
• Successfully modified N-terminal phenylalanine short peptides.
• Allowed incorporation of N-containing heterocycles into peptide settings.
• Broadened chemical modification strategies for peptide research.