An efficient protocol modifies peptides using light, broadening chemical modification options.
An efficient protocol for the modification of phenylalanine‐containing peptides is developed. The tandem debenzylation–amination process in N‐terminal phenylalanine short peptides with N ‐iodoimides proceeds under visible‐light irradiation and metal‐free conditions. This method broadens the available chemical toolbox for the modification of Phe and allows the incorporation of N‐containing heterocycles into peptide settings.
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Morales‐Ortega et al. (2026) studied this question.
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